Real-world evidence from a medical centre links high levels of potent antibodies after vaccination to a reduced risk of infection.
The genetic tweaks that make humans uniquely human may come in small parcels interspersed with DNA inherited from extinct ancestors and cousins. Only 1.5 percent to 7 percent of the collective human genetic instruction book, or genome, contains uniquely human DNA, researchers report July 16 in Science Advances. That humans-only DNA, scattered throughout the genome, tends to contain genes involved in brain development and function, hinting that brain evolution was important in making humans human. But the researchers don’t yet know exactly what the genes do and how the exclusively human tweaks to DNA near those genes may have affected brain evolution.
Howard Hughes Medical Institute’s (HHMI) Investigator Lora Hooper, HHMI Hanna Gray Fellow John Brooks, and colleagues report that mice intestinal immune systems sync with gut microbe activity to provide scheduled protection against contaminated food.
Stool miRNA profiles are associated with specific diets and support the role of lipids as a driver of epigenetic changes and host-microbial molecular interactions in the gut.
Worms show a decline in protein ubiquitination with ageing.
It is possible that proteins for which proteasomal clearance is dysregulated with ageing have an important role in the development of age-related mammalian disorders that involve protein aggregation, such as Parkinson’s disease and Alzheimer’s disease15. Therefore, understanding how the ubiquitination dynamics for different proteins change in different species with ageing could provide insight into potential strategies for treating such disorders.
Some colleges are expanding vaccine requirements or reimposing mask mandates in response to spread of Delta variant and new CDC guidance. Other institutions are finding their authority to mandate mitigation measures limited.
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